HG-9-91-01 is a potent, selective, ATP-competitive, pan-SIK (salt-inducible kinases) inhibitor with IC₅₀ values of 0.92 nM, 6.6n M and 9.6 nM for SIK1, SIK2, SIK3, respectively.HG-9-91-01 is a...
NSC-59984 is a p53 pathway activator that induces mutant p53 protein degradation via MDM2 and the ubiquitin-proteasome pathway. The EC₅₀ of NSC-59984 in most cancer cells is significantly lower than...