HNHA | B2821

HNHA is an inhibitor of Histone deacetylase (HDAC). It inhibited proliferation of HT1080 human fibrosarcoma cells with an IC₅₀ of 7.5 μM. It induced hyperacetylation, upregulation of p21 transcription and cell cycle arrest. It inhibited the growth of tumor tissue in a mouse model.

HNHA is an inhibitor of Histone deacetylase (HDAC). It inhibited proliferation of HT1080 human fibrosarcoma cells with an IC₅₀ of 7.5 μM. It induced hyperacetylation, upregulation of p21 transcription and cell cycle arrest. It inhibited the growth of tumor tissue in a mouse model.

B2821 | HNHA DataSheet

Alternate Name/Synonyms: N-hydroxy-7-naphthalen-2-ylsulfanylheptanamide, Histone deacetylase inhibitor VI, N-hydroxy-7-(2-naphthalenylthio)-heptanamide

Appearance: Crystalline solid

Formulation:

CAS Number: 926908-04-5

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₁₇H₂₁NO₂S

Molecular Weight: 303.42

Cell-Permeable?: True

Purity: ≥98%

Solubilities: ~20 mg/ml in ethanol, DMSO and DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of HDAC

MDL Number: MFCD10568146

PubChem CID: 16126782

SMILES: C1=CC=C2C=C(C=CC2=C1)SCCCCCCC(=O)NO

InChi: InChI=1S/C17H21NO2S/c19-17(18-20)9-3-1-2-6-12-21-16-11-10-14-7-4-5-8-15(14)13-16/h4-5,7-8,10-11,13,20H,1-3,6,9,12H2,(H,18,19)

InChi Key: KPNNXHVGOKRBEF-UHFFFAOYSA-N