Human CellExp™ Her2 / ErbB2, Cynomolgus Recombinant | P1347

Human Epidermal growth factor Receptor 2 (HER2) is also called ERBB2, HER-2, HER-2 /neu, NEU, NGL, TKR1 and c-erb B2, and is a protein giving higher aggressiveness in breast cancers. It is a member of the ErbB protein family, more commonly known as the epidermal growth factor receptor family. HER2 is a cell membrane surface-bound receptor tyrosine kinase and is normally involved in the signal transduction pathways leading to cell growth and differentiation. HER2 is thought to be an orphan receptor, with none of the EGF family of ligands able to activate it. Approximately 30% of breast cancers have an amplification of the HER2 gene or overexpression of its protein product. Overexpression of this receptor in breast cancer is associated with increased disease recurrence and worse prognosis. HER2 appears to play roles in development, cancer, communication at the neuromuscular junction and regulation of cell growth and differentiation.

P1347 | Human CellExp Her2 / ErbB2 Cynomolgus Recombinant DataSheet

Biomolecule/Target: ERBB2

Synonyms: ERBB2, CD340, HER-2/neu, HER2, MLN19, NEU, NGL, TKR1

Alternates names: Growth/differentiation factor 9

Taglines: Involved in the signal transduction pathways leading to cell growth and differentiation.

NCBI Gene ID #: 2661

NCBI Gene Symbol: GDF-9

Gene Source: Human

Accession #: O60383

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): Measured by its binding ability in a functional ELISA.

Biological activity: Test in process

Results: N/A

Binding Capacity: Immobilized Trastuzumab at 2 g/mL (100 L/well) can bind Cynomolgus Her2 with a linear range of 2-6 ng/mL

Unit Definition: N/A

Molecular Weight: 31.2 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Generally Trehalose is added as a protectant before lyophilization.

Reconstitution Instructions: Reconstitute in HO to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers

Amino acid sequence: N/A