Human CellExp™ PD-L1 /CD274 /B7-H1, mouse recombinant | 7428

Programmed cell death 1 ligand 1 (PD-L1) is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules and is involved in the regulation of cellular and humoral immune responses. B7-H1 is a cell surface immunoglobulin superfamily with two Ig-like domains within the extracellular region and a short cytoplasmic domain. PD-L1 is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after LPS and IFNG activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 involve in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner.

7428 | Human CellExp PD-L1 /CD274 /B7-H1 mouse recombinant DataSheet

Biomolecule/Target: PD-L1 /CD274 /B7-H1

Synonyms: PD-L1, CD274, B7-H1, PDCD1L1, PDCD1LG1

Alternates names: EPG, Epigen, PRO9904, ALGV3072, FLJ75542, EPGN, Epithelial mitogen.

Taglines: N/A

NCBI Gene ID #: 255324

NCBI Gene Symbol: EPGN

Gene Source: Human

Accession #: Q6UW88

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 98%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <1 EU/g by LAL method

Activity (Specifications/test method): N/A

Biological activity: Determined by the dose-dependent stimulation of the proliferation of murine Balb/3T3 cells. The expected ED for this effect is 150-300 ng/ml.

Results: 150-300 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 7.9 kDa

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from 0.22 m filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Reconstitution Instructions: Reconstitute in sterile dHO not less than 100 g/ml.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).

Amino acid sequence: N/A