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Human CellExp™ sIL-6 receptor, Human Recombinant | P1289
- SKU:
- 26-P1289-GEN
- Availability:
- Usually shipped in 5 working days
Description
IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R and gp130. The IL-6R chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R alone. IL-6R is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R which consists of only the extracellular domain of the IL-6R chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R chain (338 amino acid residues).
P1289 | Human CellExp sIL-6 receptor Human Recombinant DataSheet
Biomolecule/Target: sIL-6 Receptor
Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126, Membrane glycoprotein 80, gp80, IL-6R 1, Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA
Alternates names: BFP, Blue Fluorescent Protein
Taglines: A type I cytokine receptor
NCBI Gene ID #:
NCBI Gene Symbol:
Gene Source:
Accession #:
Recombinant: Yes
Source: E. coli
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: <0.1 EU/g
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 29.0 kDa
Concentration: N/A
Appearance: lyophilized powder
Physical form description: Lyophilized from 1x PBS pH 7.2.
Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml
Amino acid sequence: N/A