Human CellExp™ sIL-6 receptor, Human Recombinant | P1289

IL-6 mediates its biological effects through the type I IL-6 receptor system that consists of two chains, IL-6R and gp130. The IL-6R chain is the binding component specific to IL-6; while the gp130 only transmits signals of IL-6 when bound to IL-6R. The gp130 also can transmit signals from LIF, OSM, CNTF, IL-11 and CT-1 in conjunction with other receptor subunits. The low-affinity binding site for IL-6 is composed of IL-6R alone. IL-6R is expressed in a wide range of cells including T cells, fibroblasts and macrophages. Soluble IL-6R which consists of only the extracellular domain of the IL-6R chain, acts as an agonist of IL-6 activity at low concentrations. Recombinant human sIL-6R is a 37.6 kDa protein consisting of the extracellular domain of the IL-6R chain (338 amino acid residues).

P1289 | Human CellExp sIL-6 receptor Human Recombinant DataSheet

Biomolecule/Target: sIL-6 Receptor

Synonyms: soluble IL-6 receptor alpha, B cell stimulatory factor-2, CD126, Membrane glycoprotein 80, gp80, IL-6R 1, Interleukin-6 receptor subunit alpha, IL-6 receptor subunit alpha, IL-6R subunit alpha, IL-6R-alpha, IL-6RA

Alternates names: BFP, Blue Fluorescent Protein

Taglines: A type I cytokine receptor

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Accession #:

Recombinant: Yes

Source: E. coli

Purity by SDS-PAGEs: 97%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: <0.1 EU/g

Activity (Specifications/test method): N/A

Biological activity: N/A

Results: N/A

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 29.0 kDa

Concentration: N/A

Appearance: lyophilized powder

Physical form description: Lyophilized from 1x PBS pH 7.2.

Reconstitution Instructions: Reconstitute with dHO to 1 mg/ml

Amino acid sequence: N/A