Human Livin/BIRC7 | P1600

Livin/BIRC7 is a member of the inhibitor of apoptosis protein (IAP) family. Its inhibits apoptosis through the inhibition of CASP3, CASP7, CASP9 and shows E3 ubiquitin-protein ligase activity. It promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway. It is expressed in fetal tissues and most solid tumors in humans. Livin/BIRC7 expression is a novel prognostic marker in adult acute leukemia. It might be involved in adrenocortical tumorigenesis and represents a new molecular marker of malignancy.

P1600 | Human Livin/BIRC7 DataSheet

Biomolecule/Target :

Synonyms: KIAP, LIVIN, ML-IAP, RNF50, MLIAP

Alternates names: KIAP, LIVIN, ML-IAP, RNF50, MLIAP

Taglines: An apoptosis inhibitor protein

NCBI Gene ID #:

NCBI Gene Symbol:

Gene Source: Human

Accession #: AAH14475.1

Recombinant: YES

Source: E.Coli

Purity by SDS-PAGE: >85% as determined by SDS-PAGE

Assay: SDS-PAGE

Purity:

Assay #2:

Endotoxin Level:

Activity (Specifications/test method):

Biological activity: Human Livin/BIRC7 reversibly inhibits DEVD-AFC cleavage activity in cell extracts activated by the addition of cytochrome c and dATP. The ICâ‚…â‚€ for this effect is typically 0.6-3.0 uM.

Results:

Binding Capacity:

Unit Definition:

Molecular Weight: BIRC

Concentration:

Appearance: Liquid

Physical form description: Liquid

Reconstitution Instructions:

Amino acid sequence: A DNA sequence encoding the human Livin/BIRC7 (AAH14475.1) (Met1-Ser298) is expressed with a polyhistide tag at the C-terminus.

Handling: Centrifuge the vial prior to opening.

Usage: For Research Use Only! Not to be used in humans