Description
Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and glutathione S-transferase (GST). It activates Nrf2 regulated antioxidant/detoxifying genes. It induces cell cycle arrest with an inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins and apoptosis with the activation of caspase-9, caspase-3, and PARP in neuroblastoma cells. It is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa.
Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and glutathione S-transferase (GST). It activates Nrf2 regulated antioxidant/detoxifying genes. It induces cell cycle arrest with an inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins and apoptosis with the activation of caspase-9, caspase-3, and PARP in neuroblastoma cells. It is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa.
Alternate Name/Synonyms: 1-isothiocyanato-3-methylsulfinylpropane, IMSP, NSC 321801
Appearance:
Formulation: Solution in ethanol
CAS Number: 505-44-2
Structure Available?: True
Peptide sequence:
Salt Form: False
Molecular Formula: C₅H₉NOS₂
Molecular Weight: 163.26
Cell-Permeable?: True
Purity: ≥95%
Solubilities:
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A natural isothiocyanate from cruciferous plants
MDL Number:
PubChem CID: 10455
SMILES: CS(=O)CCCN=C=S
InChi: InChI=1S/C5H9NOS2/c1-9(7)4-2-3-6-5-8/h2-4H2,1H3
InChi Key: LELAOEBVZLPXAZ-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-80ºC |
Shipping Condition: |
Dry Ice |
Shelf Life: |
24months |