Iberin | B2827

Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and glutathione S-transferase (GST). It activates Nrf2 regulated antioxidant/detoxifying genes. It induces cell cycle arrest with an inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins and apoptosis with the activation of caspase-9, caspase-3, and PARP in neuroblastoma cells. It is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa.

Iberin is a natural isothiocyanate from cruciferous plants. It is a hydrolysis product of glucosinolate. It induces the expression of phase II detoxification enzymes, quinone reductase (QR) and glutathione S-transferase (GST). It activates Nrf2 regulated antioxidant/detoxifying genes. It induces cell cycle arrest with an inhibition of expression of Cdk2, Cdk4, and Cdk6 proteins and apoptosis with the activation of caspase-9, caspase-3, and PARP in neuroblastoma cells. It is a quorum-sensing inhibitor (QSI) of the bacterial pathogen Pseudomonas aeruginosa.

B2827 | Iberin DataSheet

Alternate Name/Synonyms: 1-isothiocyanato-3-methylsulfinylpropane, IMSP, NSC 321801

Appearance:

Formulation: Solution in ethanol

CAS Number: 505-44-2

Structure Available?: True

Peptide sequence:

Salt Form: False

Molecular Formula: C₅H₉NOS₂

Molecular Weight: 163.26

Cell-Permeable?: True

Purity: ≥95%

Solubilities:

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A natural isothiocyanate from cruciferous plants

MDL Number:

PubChem CID: 10455

SMILES: CS(=O)CCCN=C=S

InChi: InChI=1S/C5H9NOS2/c1-9(7)4-2-3-6-5-8/h2-4H2,1H3

InChi Key: LELAOEBVZLPXAZ-UHFFFAOYSA-N