IGHD Antibody| F40396-0.08ML/F40396-0.4ML/F53712-0.1ML

IGHD Antibody| F40396-0.08ML/F40396-0.4ML/F53712-0.1ML | Gentaur UK, US & Europe Distribution

Background: IgD is the major antigen receptor isotype on the surface of most peripheral B-cells, where it is coexpressed with IgM. The membrane-bound IgD (mIgD) induces the phosphorylation of CD79A and CD79B by the Src family of protein tyrosine kinases. Soluble IgD (sIgD) concentration in serum below those of IgG, IgA, and IgM but much higher than that of IgE. IgM and IgD molecules present on B cells have identical V regions and antigen-binding sites. After the antigen binds to the B-cell receptor, the secreted form sIgD is shut off. IgD is a potent inducer of TNF, IL1B, and IL1RN. IgD also induces release of IL6, IL10, and LIF from peripheral blood mononuclear cells. Monocytes seem to be the main producers of cytokines in vitro in the presence of IgD.

Format: Purified

Clone: 607CT8.4.4

Host Animal: Mouse

Clonality: Monoclonal (mouse origin)

Isotype: Mouse IgM

Species Reactivity: Human

Predicted Spacies Reactivity: N/A

Application: WB, ELISA

Application Details: Western blot: 1:100-1:250

Application Note: Titration of the IGHD antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This IGHD antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 37-64 from the human protein was used as the immunogen for this IGHD antibody.

Storage: Aliquot the IGHD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A