IL1RAP Antibody (Center) [APR33614G]

IL1RAP Antibody (Center) [APR33614G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids of human IL1RAP.

Cellular Localisation: [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted.

Molecular Weight: 65418

Clone: Polyclonal

Gene Name: IL1RAP

Gene ID: 3556

Function: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity) . Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity) . May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable) .

Summary: Tissue Location: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML) . Overexpressed in patients with chronic obstructive pulmonary disease (COPD) . Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC, IHC-P

Dilution: IHC-P--1:100~500 WB--1:2000 FC--1:25

Synonyms: Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP, C3orf13, IL1R3