LBD
IL1RAP Antibody (Center) [APR33614G]
- SKU:
- LBD-APR33614G
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- Usually ships in 5 working days
Description
IL1RAP Antibody (Center) [APR33614G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This IL1RAP antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 279-313 amino acids of human IL1RAP.
Cellular Localisation: [Isoform 1]: Cell membrane; Single-pass type I membrane protein [Isoform 3]: Secreted.
Molecular Weight: 65418
Clone: Polyclonal
Gene Name: IL1RAP
Gene ID: 3556
Function: Coreceptor for IL1RL2 in the IL-36 signaling system (By similarity) . Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (By similarity) . May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (Probable) .
Summary: Tissue Location: Detected in liver, skin, placenta, thymus and lung. Isoform 4 is predominantly expressed in brain. Overexpressed on candidate chronic myeloid leukemia (CML) stem cells, hematopoietic stem cells and mononuclear cells of patients with acute myeloid leukemia (AML) . Overexpressed in patients with chronic obstructive pulmonary disease (COPD) . Expressed in T-helper 1 (Th1) and T-helper 2 (Th2) cell subsets (PubMed:10653850) .
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, FC, IHC-P
Dilution: IHC-P--1:100~500 WB--1:2000 FC--1:25
Synonyms: Interleukin-1 receptor accessory protein, IL-1 receptor accessory protein, IL-1RAcP, Interleukin-1 receptor 3, IL-1R-3, IL-1R3, IL1RAP, C3orf13, IL1R3