LBD
INCA1 Antibody (N-term) [APR31599G]
- SKU:
- LBD-APR31599G
- Availability:
- Usually ships in 5 working days
Description
INCA1 Antibody (N-term) [APR31599G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M
Specificity: This INCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human INCA1.
Cellular Localisation: Nucleus. Cytoplasm
Molecular Weight: 26817
Clone: Polyclonal
Gene Name: INCA1
Gene ID: 388324
Function: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187) . Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity) . Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity) .
Summary: Tissue Location: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402) . Down- regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187)
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB
Dilution: WB--1:1000
Synonyms: Protein INCA1, Inhibitor of CDK interacting with cyclin A1, INCA1