INCA1 Antibody (N-term) [APR31599G]

INCA1 Antibody (N-term) [APR31599G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This INCA1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human INCA1.

Cellular Localisation: Nucleus. Cytoplasm

Molecular Weight: 26817

Clone: Polyclonal

Gene Name: INCA1

Gene ID: 388324

Function: Binds to CDK2-bound cyclins and inhibits the kinase activity of CDK2; binding to cyclins is critical for its function as CDK inhibitor (PubMed:21540187) . Inhibits cell growth and cell proliferation and may play a role in cell cycle control (By similarity) . Required for ING5-mediated regulation of S-phase progression, enhancement of Fas-induced apoptosis and inhibition of cell growth (By similarity) .

Summary: Tissue Location: Detected in testis, and at lower levels in ovary. Detected at very low levels in testis tumors (PubMed:15159402) . Down- regulated in bone marrow cells in acute myeloid and lymphoid leukemia patients as compared with normal bone marrow cells (PubMed:21540187)

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Protein INCA1, Inhibitor of CDK interacting with cyclin A1, INCA1