LBD
ING4 Antibody (C-term) [APR32869G]
- SKU:
- LBD-APR32869G
- Availability:
- Usually ships in 5 working days
Description
ING4 Antibody (C-term) [APR32869G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.
Cellular Localisation: Nucleus
Molecular Weight: 28530
Clone: Polyclonal
Gene Name: ING4
Gene ID: 51147
Function: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653) . Through chromatin acetylation it may function in DNA replication (PubMed:16387653) . May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276) . Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197) . May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197) . Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452) . Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB, IHC-P
Dilution: IHC-P--1:100~500 WB--1:1000
Synonyms: Inhibitor of growth protein 4, p29ING4, ING4