ING4 Antibody (C-term) [APR32869G]

ING4 Antibody (C-term) [APR32869G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ING4 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 162-195 amino acids from the C-terminal region of human ING4.

Cellular Localisation: Nucleus

Molecular Weight: 28530

Clone: Polyclonal

Gene Name: ING4

Gene ID: 51147

Function: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 (PubMed:16387653) . Through chromatin acetylation it may function in DNA replication (PubMed:16387653) . May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation (PubMed:15251430, PubMed:15528276) . Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA (PubMed:15029197) . May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC (PubMed:15029197) . Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) (PubMed:15897452) . Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:1000

Synonyms: Inhibitor of growth protein 4, p29ING4, ING4