IQA | B2939

IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive manner (Ki is 0.17 and 0.21 µM, respectively). It induces apoptosis in different tumor derived cell lines.

IQA is an indoloquinazoline derivative that acts as a selective and reversible casein kinase (CK2) inhibitor with an IC₅₀ of 390 nM with 100 µM ATP. It inhibits CK2 in an ATP- and GTP-competitive manner (Ki is 0.17 and 0.21 µM, respectively). It induces apoptosis in different tumor derived cell lines.

B2939 | IQA DataSheet

Alternate Name/Synonyms: 5,6-Dihydro-5-oxo-indolo[1,2-a]quinazoline-7-acetic acid; 2-(5-Oxo-7H-indolo[1,2-a]quinazolin-7-yl)acetic acid; Casein Kinase II Inhibitor IX; CGP029482

Appearance: Solid

Formulation:

CAS Number: 391670-48-7

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₇H₁₂N₂O₃

Molecular Weight: 292.29

Cell-Permeable?: True

Purity: 95%

Solubilities: 10 mg/ml in in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of CK2

MDL Number:

PubChem CID: 76844772

SMILES: C1=CC=C2C(=C1)C(C3=NC(=O)C4=CC=CC=C4N23)CC(=O)O

InChi: InChI=1S/C17H12N2O3/c20-15(21)9-12-10-5-1-3-7-13(10)19-14-8-4-2-6-11(14)17(22)18-16(12)19/h1-8,12H,9H2,(H,20,21)

InChi Key: DNABALWBHCYRNL-UHFFFAOYSA-N