Isoliquiritigenin | 2528

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants. Displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. Acts as a soluble guanylyl cyclase activator. Also displays chemoprevention by induction of phase 2 enzymes such as quinone reductase, that protect cells against reactive, toxic, and potentially carcinogenic species.

Isoliquiritigenin (ISL) is a flavonoid found in licorice root and several other plants. Displays antioxidant, anti-inflammatory, and antitumor activities as well as hepatoprotection against steatosis-induced oxidative stress. Acts as a soluble guanylyl cyclase activator. Also displays chemoprevention by induction of phase 2 enzymes such as quinone reductase, that protect cells against reactive, toxic, and potentially carcinogenic species.

2528 | Isoliquiritigenin DataSheet

Alternate Name/Synonyms: 1-​(2E,​4-​dihydroxyphenyl)-​3-​(4-​hydroxyphenyl)-​2-​propen-​1-​one; GU 17; ISL

Appearance: Yellow to orange solid

Formulation: N/A

CAS Number: 961-29-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₂O₄

Molecular Weight: 256.26

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A soluble guanylyl cyclase activator

MDL Number: MFCD00075907

PubChem CID: 638278

SMILES: C1=CC(=CC=C1C=CC(=O)C2=C(C=C(C=C2)O)O)O

InChi: InChI=1S/C15H12O4/c16-11-4-1-10(2-5-11)3-8-14(18)13-7-6-12(17)9-15(13)19/h1-9,16-17,19H/b8-3+

InChi Key: DXDRHHKMWQZJHT-FPYGCLRLSA-N