Jumonji HDM Inhibitor, JIB-04 | 2474

JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate ; it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.

JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively).

2474 | Jumonji HDM Inhibitor, JIB-04 DataSheet

Alternate Name/Synonyms: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2​-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627

Appearance: White solid

Formulation: N/A

CAS Number: 199596-05-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₇H₁₃ClN₄

Molecular Weight: 308.76

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent jumonji HDM inhibitor

MDL Number: N/A

PubChem CID: 6519698

SMILES: C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3

InChi: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+

InChi Key: YHHFKWKMXWRVTJ-OQKWZONESA-N