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Jumonji HDM Inhibitor, JIB-04 | 2474
- SKU:
- 26-2474-GEN
- Availability:
- Usually shipped in 5 working days
Description
JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively). JIB-04 is not a competitive inhibitor of α-ketoglutarate ; it selectively inhibits viability of several human cancer cell lines with little toxicity towards normal cells, and also diminishes tumor growth in xenograft mouse models.
JIB-04 (E-isomer) is a potent, cell-permeable inhibitor of Jumonji histone demethylases in vitro and in vivo. (In vitro IC₅₀ values are 230, 340, 435, 445, 855 and 1100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3 and JMJD2C respectively).
2474 | Jumonji HDM Inhibitor, JIB-04 DataSheet
Alternate Name/Synonyms: 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine; NSC693627
Appearance: White solid
Formulation: N/A
CAS Number: 199596-05-9
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₃ClN₄
Molecular Weight: 308.76
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A potent jumonji HDM inhibitor
MDL Number: N/A
PubChem CID: 6519698
SMILES: C1=CC=C(C=C1)C(=NNC2=NC=C(C=C2)Cl)C3=CC=CC=N3
InChi: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17+
InChi Key: YHHFKWKMXWRVTJ-OQKWZONESA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |