Kirromycin | B1236

Kirromycin belongs to elfermycin group of antibiotics that inhibits as a protein biosynthesis inhibitor. It is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu (EF-tu). This prevents the release of EF-Tu from the bacterial ribosome after GTP hydrolysis, inducing EF-Tu dependent hydrolysis of GTP.

Kirromycin belongs to elfermycin group of antibiotics that inhibits as a protein biosynthesis inhibitor. It is shown to interfere with the peptide transfer reaction by acting on elongation factor Tu (EF-tu). This prevents the release of EF-Tu from the bacterial ribosome after GTP hydrolysis, inducing EF-Tu dependent hydrolysis of GTP.

B1236 | Kirromycin DataSheet

Alternate Name/Synonyms: N-[7-[5-[7-(1,2-dihydro-4-hydroxy-2-oxo-3-pyridinyl)-6-methyl-7-oxo-1,3,5-heptatrienyl]tetrahydro-3,4-dihydroxy-2-furanyl]-6-methoxy-5-methyl-2,4-octadienyl]-alpha-ethyltetrahydro-2,3,4-trihydroxy-5,5-dimethyl-6-(1,3-pentadienyl)-2H-pyran-2-acetamide

Appearance: Yellow Solid

Formulation: N/A

CAS Number: 50935-71-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₄₃H₆₀N₂O₁₂

Molecular Weight: 769.9

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A protein biosynthesis inhibitor

MDL Number: MFCD00467139

PubChem CID: 101286229

SMILES: CCC(C(=O)NCC=CC=C(C)C(C(C)C1C(C(C(O1)C=CC=CC=C(C)C(=C2C(=O)C=CNC2=O)O)O)O)OC)C3(C(C(C(C(O3)C=CC=CC)(C)C)O)O)O

InChi: InChI=1S/C43H60N2O12/c1-9-11-13-21-31-42(6,7)38(50)39(51)43(54,57-31)28(10-2)40(52)44-23-17-16-19-26(4)36(55-8)27(5)37-35(49)34(48)30(56-37)20-15-12-14-18-25(3)33(47)32-29(46)22-24-45-41(32)53/h9,11-22,24,27-28,30-31,34-39,47-51,54H,10,23H2,1-8H3,(H,44,52)(H,45,53)/b11-9+,14-12+,17-16+,20-15+,21-13+,25-18+,26-19+,33-32?/t27-,28-,30-,31+,34+,35+,36-,37+,38+,39-,43-/m1/s1

InChi Key: LWXUPCAADQWXRE-QLLIXMPVSA-N