Klotho Polyclonal Antibody | BS65616

Klotho Polyclonal Antibody | BS65616 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,

Application: WB,IHC-P,

Application Range: WB=1:500-2000 IHC-P=1:100-500

Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity) . Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Klotho Polyclonal Antibody detects endogenous levels of Klotho protein.

Molecular Weight: 135 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: KL Antibody KLOT_HUMAN; Klotho peptide.

Immunogen: KLH conjugated synthetic peptide derived from human Klotho:401-500/1012

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: