BW
Klotho Polyclonal Antibody | BS65616
- SKU:
- BW-BS65616
- Availability:
- Usually ships in 5 working days
Description
Klotho Polyclonal Antibody | BS65616 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat,Dog,Pig,Cow,Horse,Rabbit,
Application: WB,IHC-P,
Application Range: WB=1:500-2000 IHC-P=1:100-500
Background: May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity) . Essential factor for the specific interaction between FGF23 and FGFR1. The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Klotho Polyclonal Antibody detects endogenous levels of Klotho protein.
Molecular Weight: 135 kD
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: KL Antibody KLOT_HUMAN; Klotho peptide.
Immunogen: KLH conjugated synthetic peptide derived from human Klotho:401-500/1012
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: affinity purified by Protein A
Pathway: