L1CAM Antibody| F44598-0.08ML/F44598-0.4ML

L1CAM Antibody| F44598-0.08ML/F44598-0.4ML | Gentaur UK, US & Europe Distribution

Background: L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: Rat

Application: WB, ELISA

Application Details: Western blot: 1:1000 (1)

Application Note: Titration of the L1CAM antibody may be required due to differences in protocols and secondary/substrate sensitivity.

1. Cleavage by ADAM10 results in 180 and 40 kDa bands while cleavage by Plasmin results in 140 and 80 kDa bands.

Status: Available

Buffer: N/A

Limitation: This L1CAM antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 1154-1182 from the human protein was used as the immunogen for this L1CAM antibody.

Storage: Aliquot the L1CAM antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A