Description
-Lactalbumin is an important whey protein in cow's milk, and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. -Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and -1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. When formed into a complex with Gal-T1, a galactosyltransferase, -lactalbumin, enhances the enzyme's affinity for glucose by about 1000 times, and inhibits the ability to polymerize multiple galactose units. This gives rise to a pathway for forming lactose by converting Gal-TI to Lactose synthase.
7286 | Lactalbumin Human Milk DataSheet
Biomolecule/Target: Lactalbumin
Synonyms: LYZL7
Alternates names: Human Growth Hormone, GH1, GH, GHN, GH-N, hGH-N, Pituitary growth hormone, Growth hormone 1, Somatotropin.
Taglines: Forms the regulatory subunit of the lactose synthase (LS) heterodimer
NCBI Gene ID #: 2688
NCBI Gene Symbol: GH1
Gene Source: Human
Accession #: P01241
Recombinant: No
Source: Human 293 cell expressed
Purity by SDS-PAGEs: 95%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: ED is typically 0.4 to 2 ng/mL. The activity was determined by the dose-dependent stimulation of the proliferation of rat lymphoma line Nb2-11 cells (prolactin indicator cell line).
Results: 0.4 to 2 ng/ml
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 22 kDa, monomer, non-glycosylated
Concentration: N/A
Appearance: Lyophilized
Physical form description: Lyophilized from de-ionized water
Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.
Amino acid sequence: N/A