Lactalbumin, Human Milk | 7286

-Lactalbumin is an important whey protein in cow's milk, and is also present in the milk of many other mammalian species. In primates, alpha-lactalbumin expression is upregulated in response to the hormone prolactin and increases the production of lactose. -Lactalbumin forms the regulatory subunit of the lactose synthase (LS) heterodimer and -1,4-galactosyltransferase (beta4Gal-T1) forms the catalytic component. Together, these proteins enable LS to produce lactose by transferring galactose moieties to glucose. As a monomer, alpha-lactalbumin strongly binds calcium and zinc ions and may possess bactericidal or antitumor activity. When formed into a complex with Gal-T1, a galactosyltransferase, -lactalbumin, enhances the enzyme's affinity for glucose by about 1000 times, and inhibits the ability to polymerize multiple galactose units. This gives rise to a pathway for forming lactose by converting Gal-TI to Lactose synthase.

7286 | Lactalbumin Human Milk DataSheet

Biomolecule/Target: Lactalbumin

Synonyms: LYZL7

Alternates names: Human Growth Hormone, GH1, GH, GHN, GH-N, hGH-N, Pituitary growth hormone, Growth hormone 1, Somatotropin.

Taglines: Forms the regulatory subunit of the lactose synthase (LS) heterodimer

NCBI Gene ID #: 2688

NCBI Gene Symbol: GH1

Gene Source: Human

Accession #: P01241

Recombinant: No

Source: Human 293 cell expressed

Purity by SDS-PAGEs: 95%

Assay: SDS-PAGE

Purity: N/A

Assay #2: N/A

Endotoxin Level: N/A

Activity (Specifications/test method): N/A

Biological activity: ED is typically 0.4 to 2 ng/mL. The activity was determined by the dose-dependent stimulation of the proliferation of rat lymphoma line Nb2-11 cells (prolactin indicator cell line).

Results: 0.4 to 2 ng/ml

Binding Capacity: N/A

Unit Definition: N/A

Molecular Weight: 22 kDa, monomer, non-glycosylated

Concentration: N/A

Appearance: Lyophilized

Physical form description: Lyophilized from de-ionized water

Reconstitution Instructions: Reconstitute in sterile PBS containing 0.1% endotoxin-free recombinant human serum albumin.

Amino acid sequence: N/A