LMCD1 Antibody (C-term) [AMM06311G]

LMCD1 Antibody (C-term) [AMM06311G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This LMCD1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 316-350 amino acids from the C-terminal region of human LMCD1.

Cellular Localisation: Cytoplasm. Nucleus. Note=May shuttle between the cytoplasm and the nucleus.

Molecular Weight: 40833

Clone: Polyclonal

Gene Name: LMCD1

Gene ID: 29995

Function: Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6- mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter (By similarity) . Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway.

Summary: Tissue Location: Expressed in the heart (at protein level) . Expressed in many tissues with highest abundance in skeletal muscle

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: LIM and cysteine-rich domains protein 1, Dyxin, LMCD1