LMTK3 Antibody (C-term) [APR17219G]

LMTK3 Antibody (C-term) [APR17219G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This LMTK3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1192-1226 amino acids from the C-terminal region of human LMTK3.

Cellular Localisation: Membrane {ECO:0000250|UniProtKB:Q5XJV6}; Single- pass membrane protein {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, axon {ECO:0000250|UniProtKB:Q5XJV6}. Cell projection, dendrite {ECO:0000250|UniProtKB:Q5XJV6}. Golgi apparatus membrane {ECO:0000250|UniProtKB:Q5XJV6}. Note=Punctate pattern in cell projections

Molecular Weight: 153661

Clone: Polyclonal

Gene Name: LMTK3

Gene ID: N/A

Function: Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804) . Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Serine/threonine-protein kinase LMTK3, Lemur tyrosine kinase 3, LMTK3, KIAA1883, TYKLM3