Lomitapide | 2876

Lomitapide is a small molecule that lowers total cholesterol levels by inhibiting microsomal triglyceride transfer protein (MTTP) and preventing the assembly of apoB-containing lipoproteins and VLDL synthesis. Lomitapide is also a substrate and inhibitor of CYP3A4.

Lomitapide is a small molecule that lowers total cholesterol levels by inhibiting microsomal triglyceride transfer protein (MTTP) and preventing the assembly of apoB-containing lipoproteins and VLDL synthesis. Lomitapide is also a substrate and inhibitor of CYP3A4.

2876 | Lomitapide DataSheet

Alternate Name/Synonyms: N-(2,2,2-trifluoroethyl)-9-(4-(4-(4'-(trifluoromethyl)-[1,1'-biphenyl]-2-ylcarboxamido)piperidin-1-yl)butyl)-9H-fluorene-9-carboxamide; BMS201038; AEGR773

Appearance: Off-white solid

Formulation: N/A

CAS Number: 182431-12-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₉H₃₇F₆N₃O₂

Molecular Weight: 693.72

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A microsomal triglyceride transfer protein (MTP) inhibitor

MDL Number: N/A

PubChem CID: 9853053

SMILES: C1CN(CCC1NC(=O)C2=CC=CC=C2C3=CC=C(C=C3)C(F)(F)F)CCCCC4(C5=CC=CC=C5C6=CC=CC=C64)C(=O)NCC(F)(F)F

InChi: InChI=1S/C39H37F6N3O2/c40-38(41,42)25-46-36(50)37(33-13-5-3-10-30(33)31-11-4-6-14-34(31)37)21-7-8-22-48-23-19-28(20-24-48)47-35(49)32-12-2-1-9-29(32)26-15-17-27(18-16-26)39(43,44)45/h1-6,9-18,28H,7-8,19-25H2,(H,46,50)(H,47,49)

InChi Key: MBBCVAKAJPKAKM-UHFFFAOYSA-N