MATK/Lsk (V157) polyclonal Antibody | BS9181

MATK/Lsk (V157) polyclonal Antibody | BS9181 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat

Application: WB IHC

Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200

Background: For instance, a mutant of c-Src, in which Y527 is replaced by phenylalanine, is transforming and displays 5 to 10-fold elevated kinase activity compared to its normal counterpart. Csk has been identified as a Src related tyrosine kinase having both SH2 and SH3 domains and a catalytic domain but lacking sequences amino terminal to the SH3 domain as well as the carboxy-terminal regulatory sequences. Csk phosphorylates Src on Y527 and also down regulates Lyn, Fyn and Lck by tyrosine phosphorylation of carboxy-terminal regulatory sites. A Csk-like protein- tyrosine kinase of mouse origin (Ctk), also designated Ntk, and its human homolog, Lsk, have also been described.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: Lsk (V157) polyclonal Antibody detects endogenous levels of Lsk protein.

Molecular Weight: ~ 56 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Megakaryocyte-associated tyrosine-protein kinase; CSK homologous kinase; CHK; Hematopoietic consensus tyrosine-lacking kinase; Protein kinase HYL; Tyrosine-protein kinase CTK; MATK; CTK; HYL

Immunogen: Synthetic peptide, corresponding to amino acids 140-180 of Human Lsk.

Conjugate: N/A

Modification: N/A

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: N/A