MCM3 Antibody| F43448-0.08ML/F43448-0.4ML/R30735

MCM3 Antibody| F43448-0.08ML/F43448-0.4ML/R30735 | Gentaur UK, US & Europe Distribution

Background: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq].

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Bovine

Application: WB, ELISA

Application Details: Western blot: 1:1000

Application Note: Titration of the MCM3 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This MCM3 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 36-64 from the human protein was used as the immunogen for this MCM3 antibody.

Storage: Aliquot the MCM3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A