MCT1 (SLC16A1) Antibody (C-term) [APR31985G]

MCT1 (SLC16A1) Antibody (C-term) [APR31985G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This MCT1 (SLC16A1) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 430-460 amino acids from the C-terminal region of human MCT1 (SLC16A1) .

Cellular Localisation: Cell membrane; Multi-pass membrane protein

Molecular Weight: 53944

Clone: Polyclonal

Gene Name: SLC16A1

Gene ID: 6566

Function: Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis.

Summary: Tissue Location: Detected in heart and in blood lymphocytes and monocytes (at protein level) . Widely expressed

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Monocarboxylate transporter 1, MCT 1, Solute carrier family 16 member 1, SLC16A1, MCT1