Description
Cell-permeable. A selective inhibitor of Dnm1 GTPase (IC₅₀ =1-10 µM). Inhibits mitochondrial outer membrane permeabilization. Inhibits mitochondrial division and apoptosis.
Mdivi-1 is a selective inhibitor of Dnm1 GTPase (IC₅₀ =1-10 µM). Inhibits mitochondrial outer membrane permeabilization. Inhibits mitochondrial division and apoptosis.
Alternate Name/Synonyms: 3-(2,4-Dichloro-5-methoxyphenyl)-2-sulfanyl-4(3H)-quinazolinone
Appearance: White solid
Formulation: N/A
CAS Number: 338967-87-6
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₅H₁₀Cl₂N₂O₂S
Molecular Weight: 353.23
Cell-Permeable?: Yes
Purity: ≥98% by TLC
Solubilities: DMSO (~25 mg/ml)
Handling: Protect from light and air
Country of Origin: USA
Tag Line: A mitochondrial division inhibitor
MDL Number: MFCD00974506
PubChem CID: 3825829
SMILES: COC1=C(C=C(C(=C1)N2C(=O)C3=CC=CC=C3NC2=S)Cl)Cl
InChi: InChI=1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChi Key: NZJKEVWTYMOYOR-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |