MDL 28170 | 2195

A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.

MDL 28170 is a potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.

2195 | MDL 28170 DataSheet

Alternate Name/Synonyms: Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III

Appearance: White solid

Formulation: N/A

CAS Number: 88191-84-8

Structure Available?: Yes

Peptide sequence: Z-Val-Phe-CHO

Salt Form: No

Molecular Formula: C₂₂H₂₆N₂O₄

Molecular Weight: 382.45

Cell-Permeable?: Yes

Purity: ≥95% by HPLC

Solubilities: DMSO (200 mM)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent calpain and cathepsin B inhibitor

MDL Number: MFCD00798796

PubChem CID: 9907994

SMILES: CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2

InChi: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)

InChi Key: NGBKFLTYGSREKK-UHFFFAOYSA-N