Description
A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Aβ formation by inhibiting the formation of intermediate Aβ46 and protecting Aβ from degradation.
MDL 28170 is a potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25 nM respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo.
Alternate Name/Synonyms: Z-Val-Phe-CHO; Carbobenzoxy-valinyl-phenylalaninal; Calpain Inhibitor III
Appearance: White solid
Formulation: N/A
CAS Number: 88191-84-8
Structure Available?: Yes
Peptide sequence: Z-Val-Phe-CHO
Salt Form: No
Molecular Formula: C₂₂H₂₆N₂O₄
Molecular Weight: 382.45
Cell-Permeable?: Yes
Purity: ≥95% by HPLC
Solubilities: DMSO (200 mM)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: A potent calpain and cathepsin B inhibitor
MDL Number: MFCD00798796
PubChem CID: 9907994
SMILES: CC(C)C(C(=O)NC(CC1=CC=CC=C1)C=O)NC(=O)OCC2=CC=CC=C2
InChi: InChI=1S/C22H26N2O4/c1-16(2)20(24-22(27)28-15-18-11-7-4-8-12-18)21(26)23-19(14-25)13-17-9-5-3-6-10-17/h3-12,14,16,19-20H,13,15H2,1-2H3,(H,23,26)(H,24,27)
InChi Key: NGBKFLTYGSREKK-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24months |