MG-132 | 1703

A cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. Activates c-Jun N-terminal kinase (JNK1), which initiates apoptosis. Inhibits NF-kB activation (IC₅₀ = 3 µM). Prevents γ-secretase cleavage.

MG-132 is a cell-permeable, potent, and reversible proteasome inhibitor (Ki = 4 nM). Reduces degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities.

1703 | MG-132 DataSheet

Alternate Name/Synonyms: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 133407-82-6

Structure Available?: Yes

Peptide sequence: Z-Leu-Leu-Leu-CHO; Z-LLL-CHO

Salt Form: No

Molecular Formula: C₂₆H₄₁N₃O₅

Molecular Weight: 475.6

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (10 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A proteasome inhibitor

MDL Number: MFCD00674886

PubChem CID: 462382

SMILES: CC(C)CC(C=O)NC(=O)C(CC(C)C)NC(=O)C(CC(C)C)NC(=O)OCC1=CC=CC=C1

InChi: InChI=1S/C26H41N3O5/c1-17(2)12-21(15-30)27-24(31)22(13-18(3)4)28-25(32)23(14-19(5)6)29-26(33)34-16-20-10-8-7-9-11-20/h7-11,15,17-19,21-23H,12-14,16H2,1-6H3,(H,27,31)(H,28,32)(H,29,33)/t21-,22-,23-/m0/s1

InChi Key: TZYWCYJVHRLUCT-VABKMULXSA-N