Migalastat hydrochloride | B2404

Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to α-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes.

Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to α-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes.

B2404 | Migalastat hydrochloride DataSheet

Alternate Name/Synonyms: 1,5-Dideoxy-1,5-imino-D-galactitol, AT1001, 1-Deoxygalactostatin, 1-Deoxygalactonojirimycin, AT-1001, GR181413A

Appearance: Yellow solid

Formulation:

CAS Number: 75172-81-5

Structure Available?:

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₆H₁₃NO₄ • HCl

Molecular Weight: 199.6

Cell-Permeable?: True

Purity: ≥98%

Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A competititve inhibitor of α-galactosidase

MDL Number: MFCD00269962

PubChem CID: 11644097

SMILES: C1C(C(C(C(N1)CO)O)O)O.Cl

InChi: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1

InChi Key: ZJIHMALTJRDNQI-OLALXQGDSA-N