26
Migalastat hydrochloride | B2404
- SKU:
- 26-B2404-GEN
- Availability:
- Usually shipped in 5 working days
Description
Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to α-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes.
Migalastat hydrochloride is a pharmacological chaperone that acts as a selective and competitive inhibitor of α-galactosidase (IC₅₀ = 40 nM). At subinhibitory concentrations, 1-Deoxygalactonojirimycin binds to α-galactosidase and chaperones unstable enzyme variants through the endoplasmic reticulum, allowing its movement into lysosomes.
B2404 | Migalastat hydrochloride DataSheet
Alternate Name/Synonyms: 1,5-Dideoxy-1,5-imino-D-galactitol, AT1001, 1-Deoxygalactostatin, 1-Deoxygalactonojirimycin, AT-1001, GR181413A
Appearance: Yellow solid
Formulation:
CAS Number: 75172-81-5
Structure Available?:
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₆H₁₃NO₄ • HCl
Molecular Weight: 199.6
Cell-Permeable?: True
Purity: ≥98%
Solubilities: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A competititve inhibitor of α-galactosidase
MDL Number: MFCD00269962
PubChem CID: 11644097
SMILES: C1C(C(C(C(N1)CO)O)O)O.Cl
InChi: InChI=1S/C6H13NO4.ClH/c8-2-3-5(10)6(11)4(9)1-7-3;/h3-11H,1-2H2;1H/t3-,4+,5+,6-;/m1./s1
InChi Key: ZJIHMALTJRDNQI-OLALXQGDSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |