Miglustat hydrochloride | B3056

Miglustat is an inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and β-glucosidase 2 with IC50 values of 32 and 81 μM respectively. Miglustat is used for the treatment of type 1 Gaucher’s disease. It is an inhibitor of HIV replication in vitro. It shows activity against SARS-CoV-2 in vitro with EC50 values in the micromolar range.

Miglustat is an inhibitor of the N-linked oligosaccharide processing enzymes α-glucosidase I and II. It inhibits rat testicular enzymes ceramide-glucosyltransferase and β-glucosidase 2 with IC50 values of 32 and 81 μM respectively. Miglustat is used for the treatment of type 1 Gaucher’s disease. It is an inhibitor of HIV replication in vitro. It shows activity against SARS-CoV-2 in vitro with EC50 values in the micromolar range.

B3056 | Miglustat hydrochloride DataSheet

Alternate Name/Synonyms: N-Butyldeoxynojirimycin hydrochloride; NB-DNJ, HCl; (2R,3R,4R,5S)-1-butyl-2-(hydroxymethyl)piperidine-3,4,5-triol hydrochloride; OGT918

Appearance: White solid

Formulation:

CAS Number: 210110-90-0

Structure Available?: TRUE

Peptide sequence:

Salt Form: TRUE

Molecular Formula: C₁₀H₂₂ClNO₄

Molecular Weight: 255.74

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: ~10 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of α-glucosidase I and II

MDL Number: MFCD00269940

PubChem CID: 6603107

SMILES: CCCCN1CC(C(C(C1CO)O)O)O.Cl

InChi: InChI=1S/C10H21NO4.ClH/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12;/h7-10,12-15H,2-6H2,1H3;1H/t7-,8+,9-,10-;/m1./s1

InChi Key: QPAFAUYWVZMWPR-ZSOUGHPYSA-N