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Mitomycin C | sc-3514A

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SKU:: sc-3514A | sc-3514 | sc-3514B-GEN
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Availability:: IN STOCK

€300.00

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Description
Additional Information

Description

Mitomycin C | sc-3514A

Mitomycin C is part of a family of azidine natural products. It is a DNA crosslinking and damaging agent, making it a useful antibiotic and antitumor compound. When crosslinking, Mitomycin C displays absolute specificity and high efficiency for the CpG sequence. Mammalian Cells treated with Mitomycin C (0.4 mg/mL for 5 min) can undergo apoptosis through upregulation of Bad, Fas, FasL and phosphorylated p53 along with activation of caspase-3, caspase-8, and caspase-9 activating both the intrinsic and extrinsic pathway for apoptosis.

Usage :

Stable for up to 1 year after receipt when stored at -20°C. Stock solutions should be aliquoted and stored at -20°C for up to 1 month. Protect from light, moisture sensitive.

Appearance :

Powder

Physical State :

Solid

Derived From :

Streptomyces caespitosus

Solubility :

Soluble in water (0.5 mg/ml), 100% ethanol (warm) (1 mg/ml), DMSO (15 mg/ml), and methanol.

Storage :

Store at -20° C

Melting Point :

>360° C

Boiling Point :

~581.8° C at 760 mmHg (Predicted)

Density :

~1.6 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.68 (Predicted)

IC50 :

Cytotoxicity against PC3 cells : EC₅₀50 = 0.14 µM (human); Cytotoxicity against A549 cells: EC₅₀50 = 0.43 µM (human); 2780/DOX ovarian cancer cell line: IC₅₀ = 0.2 µM; promyelocytic leukemic (HL-60) cells: IC₅₀ = 0.05 µM (human); SMMC-7721 (Hepatocellular carcinoma cells): IC₅₀ = 2.44 µg/ml (Homo sapiens); P388 (Lymphoma cells): IC₅₀ = 0.01 µg/ml (Mus musculus)

pK Values :

pK_a: 3.2, 6.5, 13.27, pK_b: 5.08

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