Description
MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1) activity and suppresses platelet aggregation.
MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1) activity and suppresses platelet aggregation.
Alternate Name/Synonyms: 3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2,2 -dimethyl-propanoic acid; MK886; L-663,536; L663,536
Appearance: Crystalline solid
Formulation:
CAS Number: 118414-82-7
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₇H₃₄ClNOS
Molecular Weight: 472.08
Cell-Permeable?: True
Purity: ≥98%
Solubilities: >40 mg/ml in DMSO
Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Country of Origin: USA
Tag Line: A leukotriene antagonist
MDL Number:
PubChem CID: 3651377
SMILES: CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl
InChi: InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)
InChi Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20ºC |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |