MK-886 | B2517

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1) activity and suppresses platelet aggregation.

MK-886 is a potent and selective inhibitor of 5-lipoxygenase-activating protein (FLAP) that prevents 5-lipoxygenase activation in vivo and inhibits leukotriene biosynthesis in leukocytes (IC₅₀ of 2.5 nM). MK-886 also inhibits cyclooxygenase-1 (COX-1) activity and suppresses platelet aggregation.

B2517 | MK-886 DataSheet

Alternate Name/Synonyms: 3-[3-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-yl-indol-2-yl]-2,2 -dimethyl-propanoic acid; MK886; L-663,536; L663,536

Appearance: Crystalline solid

Formulation:

CAS Number: 118414-82-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₇H₃₄ClNOS

Molecular Weight: 472.08

Cell-Permeable?: True

Purity: ≥98%

Solubilities: >40 mg/ml in DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A leukotriene antagonist

MDL Number:

PubChem CID: 3651377

SMILES: CC(C)C1=CC2=C(C=C1)N(C(=C2SC(C)(C)C)CC(C)(C)C(=O)O)CC3=CC=C(C=C3)Cl

InChi: InChI=1S/C27H34ClNO2S/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18/h8-14,17H,15-16H2,1-7H3,(H,30,31)

InChi Key: QAOAOVKBIIKRNL-UHFFFAOYSA-N