Description
ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).
Alternate Name/Synonyms: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide
Appearance: Crystalline solid
Formulation: N/A
CAS Number: 1035072-16-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₂₃H₂₂Cl₂N₂O₃S
Molecular Weight: 477.4
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>20 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A GPX4 (glutathione peroxidase 4) inhibitor
MDL Number: N/A
PubChem CID: 3689413
SMILES: COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl
InChi: InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)
InChi Key: UNVKYJSNMVDZJE-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |