ML-162 | B2304

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

ML-162 is a GPX4 (glutathione peroxidase 4) inhibitor that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC₅₀s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively).

B2304 | ML-162 DataSheet

Alternate Name/Synonyms: α-[(2-chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thiopheneacetamide

Appearance: Crystalline solid

Formulation: N/A

CAS Number: 1035072-16-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₃H₂₂Cl₂N₂O₃S

Molecular Weight: 477.4

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>20 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A GPX4 (glutathione peroxidase 4) inhibitor

MDL Number: N/A

PubChem CID: 3689413

SMILES: COC1=C(C=C(C=C1)N(C(C2=CC=CS2)C(=O)NCCC3=CC=CC=C3)C(=O)CCl)Cl

InChi: InChI=1S/C23H22Cl2N2O3S/c1-30-19-10-9-17(14-18(19)25)27(21(28)15-24)22(20-8-5-13-31-20)23(29)26-12-11-16-6-3-2-4-7-16/h2-10,13-14,22H,11-12,15H2,1H3,(H,26,29)

InChi Key: UNVKYJSNMVDZJE-UHFFFAOYSA-N