ML-210 | B2710

ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the lipoxygenase inhibitor PD 146176 (Cat. No. B2313). ML-210 displays anti-cancer activity.

ML-210 is a selective and covalent inhibitor of glutathione peroxidase 4 (GPX4). ML-210 binds the GPX4 selenocysteine residue. It reduces viability of mesenchymal-state KP4 cells, an effect that can be blocked by the lipoxygenase inhibitor PD 146176 (Cat. No. B2313). ML-210 displays anti-cancer activity.

B2710 | ML-210 DataSheet

Alternate Name/Synonyms: [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone,DPI10

Appearance: Off-white solid

Formulation:

CAS Number: 1360705-96-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₀Cl₂N₄O₄

Molecular Weight: 475.32

Cell-Permeable?: TRUE

Purity: ≥98%

Solubilities: >20 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A glutathione peroxidase 4 (GPX4) inhibitor

MDL Number:

PubChem CID: 49766530

SMILES: CC1=C(C(=NO1)C(=O)N2CCN(CC2)C(C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl)[N+](=O)[O-]

InChi: InChI=1S/C22H20Cl2N4O4/c1-14-20(28(30)31)19(25-32-14)22(29)27-12-10-26(11-13-27)21(15-2-6-17(23)7-3-15)16-4-8-18(24)9-5-16/h2-9,21H,10-13H2,1H3

InChi Key: VIBHJPDPEVVDTB-UHFFFAOYSA-N