Description
ML161 is an allosteric Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC₅₀ = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Also inhibits thrombin-induced platelet activation.
ML161 is an allosteric Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC₅₀ = 0.26 μM for the inhibition of platelet P-selectin expression on human platelets). Also inhibits thrombin-induced platelet activation.
Alternate Name/Synonyms: 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide
Appearance: Brown solid
Formulation: N/A
CAS Number: 423735-93-7
Structure Available?: Y
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₇H₁₇BrN₂O₂
Molecular Weight: 361.23
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~ 30 mg/ml) or EtOH (~ 30 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: An allosteric Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation
MDL Number: MFCD03063772
PubChem CID: 1048267
SMILES: CCCC(=O)NC1=CC=CC(=C1)NC(=O)C2=CC=CC=C2Br
InChi: InChI=1S/C17H17BrN2O2/c1-2-6-16(21)19-12-7-5-8-13(11-12)20-17(22)14-9-3-4-10-15(14)18/h3-5,7-11H,2,6H2,1H3,(H,19,21)(H,20,22)
InChi Key: DFOVLSMXPWPCFH-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |