ML243 | 2515

ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC₅₀ = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.

ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC₅₀ = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.

2515 | ML243 DataSheet

Alternate Name/Synonyms: (2E)​-​N-​​(4,​​5-​​dihydro-​​2-​​thiazolyl)​-​​3-​​(4-​​ethylphenyl)​-​2-​​propenamide; CID-50910523

Appearance: White solid

Formulation: N/A

CAS Number: 1426576-80-8

Structure Available?: Yes

Peptide sequence: No

Salt Form: No

Molecular Formula: C₁₄H₁₆N₂OS

Molecular Weight: 260.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (5 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A Cancer Cell Stem cell inhibitor

MDL Number: N/A

PubChem CID: 50910523

SMILES: CCC1=CC=C(C=C1)C=CC(=O)NC2=NCCS2

InChi: InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+

InChi Key: MTLJBAFNMHPGBV-BQYQJAHWSA-N