Description
ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC₅₀ = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.
ML-243 is a selective inhibitor of cancer stem cells. Displays 32-fold selective inhibition of a breast cancer stem cell-like cell line (EC₅₀ = 2.0 µM) over a control (mammary epithelial) cell line (EC₅₀ = 64 µM). It weakly antagonizes the adenosine A2A receptor (IC₅₀ = 10 µM) and has no effect on 68 other targets commonly used in drug discovery for lead profiling.
Alternate Name/Synonyms: (2E)-N-(4,5-dihydro-2-thiazolyl)-3-(4-ethylphenyl)-2-propenamide; CID-50910523
Appearance: White solid
Formulation: N/A
CAS Number: 1426576-80-8
Structure Available?: Yes
Peptide sequence: No
Salt Form: No
Molecular Formula: C₁₄H₁₆N₂OS
Molecular Weight: 260.35
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (5 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A Cancer Cell Stem cell inhibitor
MDL Number: N/A
PubChem CID: 50910523
SMILES: CCC1=CC=C(C=C1)C=CC(=O)NC2=NCCS2
InChi: InChI=1S/C14H16N2OS/c1-2-11-3-5-12(6-4-11)7-8-13(17)16-14-15-9-10-18-14/h3-8H,2,9-10H2,1H3,(H,15,16,17)/b8-7+
InChi Key: MTLJBAFNMHPGBV-BQYQJAHWSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |