Mouse Adrbk1 Antibody (C-term) [APR31160G]

Mouse Adrbk1 Antibody (C-term) [APR31160G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This Mouse Adrbk1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 645-674 amino acids from the C-terminal region of mouse Adrbk1.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P21146}. Cell membrane {ECO:0000250|UniProtKB:P21146}

Molecular Weight: 79639

Clone: Polyclonal

Gene Name: Grk2 {ECO:0000312|MGI:MGI:87940}

Gene ID: 110355

Function: Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them (By similarity) . Key regulator of LPAR1 signaling (By similarity) . Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor (By similarity) . Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (By similarity) . Positively regulates ciliary smoothened (SMO) - dependent Hedgehog (Hh) signaling pathway by facilitating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity) . Inhibits relaxation of airway smooth muscle in response to blue light (PubMed:30284927) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Beta-adrenergic receptor kinase 1, Beta-ARK-1, G-protein-coupled receptor kinase 2, Adrbk1, Grk2