MOUSE Bcar1 Antibody (Center) [APR04569G]

MOUSE Bcar1 Antibody (Center) [APR04569G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This MOUSE Bcar1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 322-348 amino acids from the Central region of mouse Bcar1.

Cellular Localisation: Cell junction, focal adhesion. Cytoplasm Cell projection, axon Note=Unphosphorylated form localizes in the cytoplasm (PubMed:22801373) . Localizes to focal adhesion sites following integrin engagement (PubMed:22801373) .

Molecular Weight: 94285

Clone: Polyclonal

Gene Name: Bcar1

Gene ID: 12927

Function: Docking protein which plays a central coordinating role for tyrosine kinase-based signaling related to cell adhesion (By similarity) . Implicated in induction of cell migration and cell branching (PubMed:25499443) . Involved in the BCAR3-mediated inhibition of TGFB signaling (PubMed:25499443) .

Summary: Tissue Location: Expressed in olfactory sensory neurons (at protein level) (PubMed:20881139) . Expressed abundantly in the liver, lung, brain, and at lower levels in the heart (at protein level) (PubMed:19365570) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Breast cancer anti-estrogen resistance protein 1, CRK-associated substrate, p130cas, Bcar1, Cas, Crkas